About
Titles
Associate Professor of Medicine
Director of Heart Failure Research, Cardiovascular Medicine; Co-Director Heart & Vascular Center Clinical Research, Heart & Vascular Center
Biography
My clinical training is as an advanced heart failure physician with formal research training in patient oriented translational research. My research program is supported by NIH and investigator-initiated industry sources and uses techniques of both translational and clinical research to further the mechanistic understanding of cardiac-renal interactions, fluid and sodium homeostasis, and diuretic resistance. The primary approach of my current research program is prospective mechanistic human studies in heart failure and kidney disease patients, for which we have established extensive infrastructure. N My lab has extensive expertise in biomarker research has established and maintains an extensive bioassay resource with the capability to determine an extensive range of analytes in human biological samples with complexity ranging from simple serum chemistries to complex analytes such as ultra-trace lithium by inductively coupled plasma mass spectrometry, deuterium concentration by IRMS, high dimension multiplex protein assays, and large and small molecules by liquid chromatography mass spectrometry.
Appointments
Cardiovascular Medicine
Associate Professor on Term
Primary
Cardiovascular Medicine
Other Departments & Organizations
- Cardiovascular Medicine
- Heart Failure Program
- Heart Transplant and Left Ventricular Assist Device Program
- Internal Medicine
- Yale Cardiovascular Research Center (YCVRC)
- Yale Medicine
- Yale Ventures
Education & Training
- Fellowship
- Hospital of the University of Pennsylvania (2012)
- MS
- University of Pennsylvania Medical School (2012)
- Research Fellowship
- Hospital of the University of Pennsylvania (2011)
- Fellowship
- Hospital of the University of Pennsylvania (2009)
- Residency
- Hospital of the University of Pennsylvania (2007)
- Internship
- Hospital of the University of Pennsylvania (2005)
- MD
- University of Florida (2004)
Research
Overview
Medical Subject Headings (MeSH)
Cardio-Renal Syndrome; Diuretics; Heart Failure; Kidney Diseases; Sodium
ORCID
0000-0001-5285-0419
Research at a Glance
Yale Co-Authors
Frequent collaborators of Jeffrey Testani's published research.
Publications Timeline
A big-picture view of Jeffrey Testani's research output by year.
Research Interests
Research topics Jeffrey Testani is interested in exploring.
F. Perry Wilson, MD, MSCE
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View 48 Common Publications
Veena Rao, PhD
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View 36 Common Publications
Christopher Maulion, MD
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View 20 Common Publications
Jeffrey Turner, MD
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View 13 Common Publications
Dennis G Moledina, MD, PhD, FASN
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View 11 Common Publications
Harlan Krumholz, MD, SM
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View 7 Common Publications
238Publications
12,199Citations
Heart Failure
14 Researchers
View 149 Related Publications
Diuretics
Researcher
View 43 Related Publications
Sodium
Researcher
View 22 Related Publications
Cardio-Renal Syndrome
2 Researchers
View 12 Related Publications
Kidney Diseases
10 Researchers
View 9 Related Publications
Publications
2024
Bladder Symptoms Prvoked by Short, Rapid Acting Loop Diuretics: A Frequent But Often Overlooked Problem
Wilcox C, Pourafshar N, Han K, Shah S, Sussman R, Testani J, Packer M, Rossignol P, Zannad F, Pitt B, Shah S. Bladder Symptoms Prvoked by Short, Rapid Acting Loop Diuretics: A Frequent But Often Overlooked Problem. American Journal Of Hypertension 2024, hpae139. PMID: 39485998, DOI: 10.1093/ajh/hpae139.
Peer-Reviewed Original Research
Altmetric
Concepts
Dapagliflozin enhances arterial and venous compliance during exercise in heart failure with preserved ejection fraction
Tada A, Burkhoff D, Naser J, Harada T, Pourmussa B, Reddy Y, Jensen M, Carter R, Testani J, Chirinos J, Borlaug B. Dapagliflozin enhances arterial and venous compliance during exercise in heart failure with preserved ejection fraction. European Heart Journal 2024, 45: ehae666.782. DOI: 10.1093/eurheartj/ehae666.782.
Peer-Reviewed Original Research
Concepts
Effects of dapagliflozin on body composition and its relation to hemodynamics in heart failure with preserved ejection fraction: the CAMEO-DAPA randomized clinical trial
Naser J, Tada A, Harada T, Reddy Y, Carter R, Testani J, Jensen M, Borlaug B. Effects of dapagliflozin on body composition and its relation to hemodynamics in heart failure with preserved ejection fraction: the CAMEO-DAPA randomized clinical trial. European Heart Journal 2024, 45: ehae666.1044. DOI: 10.1093/eurheartj/ehae666.1044.
Peer-Reviewed Original Research
Concepts
Sex differences in proteomics of cardiovascular disease: results from the Yale-CMD registry
Liu Y, Wang Z, Collins S, Testani J, Kleinstein S, Safdar B. Sex differences in proteomics of cardiovascular disease: results from the Yale-CMD registry. European Heart Journal 2024, 45: ehae666.3091. DOI: 10.1093/eurheartj/ehae666.3091.
Peer-Reviewed Original Research
Concepts
Early, Individualized Recommendations for Hospitalized Patients With Acute Kidney Injury
Aklilu A, Menez S, Baker M, Brown D, Dircksen K, Dunkley K, Gaviria S, Farrokh S, Faulkner S, Jones C, Kadhim B, Le D, Li F, Makhijani A, Martin M, Moledina D, Coronel-Moreno C, O’Connor K, Shelton K, Shvets K, Srialluri N, Tan J, Testani J, Corona-Villalobos C, Yamamoto Y, Parikh C, Wilson F, Sundararajan A, Wang A, Schretlen C, Singel D, Moss E, Aune F, Iantosca G, Zou G, Chernova I, Bitzel J, Hernandez J, Lindsley J, Dane K, Orias M, Mehta P, Zassman-Isner S, Wen Y, Freeman N. Early, Individualized Recommendations for Hospitalized Patients With Acute Kidney Injury. JAMA 2024, 332 PMID: 39454050, DOI: 10.1001/jama.2024.22718.
Peer-Reviewed Original Research
Altmetric
Concepts
Timing of Acute eGFR Declines in Acute Heart Failure and Their Association with Cardiovascular and Kidney Outcomes
McCallum W, Tighiouart H, Tuttle M, Lala-Trindade A, Costanzo M, Bautista I, Oka T, Testani J, Konstam M, Sarnak M. Timing of Acute eGFR Declines in Acute Heart Failure and Their Association with Cardiovascular and Kidney Outcomes. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024cax7nzke. DOI: 10.1681/asn.2024cax7nzke.
Peer-Reviewed Original Research
Concepts
Effects of Sodium-Glucose Cotransporter-2 Inhibitors on Kidney Outcomes across Baseline Cardiovascular-Kidney-Metabolic Conditions: A Systematic Review and Meta-Analyses.
Siddiqi T, Cherney D, Siddiqui H, Jafar T, Januzzi J, Khan M, Levin A, Marx N, Rangaswami J, Testani J, Usman M, Wanner C, Zannad F, Butler J. Effects of Sodium-Glucose Cotransporter-2 Inhibitors on Kidney Outcomes across Baseline Cardiovascular-Kidney-Metabolic Conditions: A Systematic Review and Meta-Analyses. Journal Of The American Society Of Nephrology 2024 PMID: 39230974, DOI: 10.1681/asn.0000000000000491.
Peer-Reviewed Original Research
Citations
Altmetric
Concepts
Effects of Sotagliflozin on Health Status in Patients With Worsening HeartFailure Results From SOLOIST-WHF
Bhatt A, Bhatt D, Steg P, Szarek M, Cannon C, Leiter L, McGuire D, Lewis J, Riddle M, Voors A, Metra M, Lund L, Testani J, Wilcox C, Davies M, Pitt B, Kosiborod M. Effects of Sotagliflozin on Health Status in Patients With Worsening Heart Failure Results From SOLOIST-WHF. Journal Of The American College Of Cardiology 2024, 84: 1078-1088. PMID: 39260929, DOI: 10.1016/j.jacc.2024.06.036.
Peer-Reviewed Original Research
Citations
Altmetric
MeSH Keywords and Concepts
Inpatient Use of Guideline-Directed Medical Therapy During HeartFailure Hospitalizations Among Community-Based Health Systems
Zheng J, Sandhu A, Bhatt A, Collins S, Flint K, Fonarow G, Fudim M, Greene S, Heidenreich P, Lala A, Testani J, Varshney A, Wi R, Ambrosy A. Inpatient Use of Guideline-Directed Medical Therapy During Heart Failure Hospitalizations Among Community-Based Health Systems. JACC Heart Failure 2024 PMID: 39269395, DOI: 10.1016/j.jchf.2024.08.004.
Peer-Reviewed Original Research
Altmetric
Concepts
Mechanistic Differences between Torsemide and Furosemide.
Rao V, Cox Z, Ivey-Miranda J, Neville D, Balkcom N, Moreno-Villagomez J, Ramos-Mastache D, Maulion C, Bellumkonda L, Tang W, Collins S, Velazquez E, Mentz R, Wilson F, Turner J, Wilcox C, Ellison D, Fang J, Testani J. Mechanistic Differences between Torsemide and Furosemide. Journal Of The American Society Of Nephrology 2024 PMID: 39196651, DOI: 10.1681/asn.0000000000000481.
Peer-Reviewed Original Research
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Concepts
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Clinical Trials
Current Trials
Mechanisms of Diuretic Resistance in Heart Failure (MsDR)
HIC ID2000032328RolePrincipal InvestigatorPrimary Completion Date03/31/2028
Recruiting ParticipantsGenderBothAge18+ years
Heart/Cardiovascular
Ertugliflozin in Acute Heart Failure
HIC ID2000027951RolePrincipal InvestigatorPrimary Completion Date01/31/2022
Recruiting ParticipantsGenderBothAge18+ years
Heart/Cardiovascular
Academic Achievements & Community Involvement
activity Reprieve cardiovascualr
Advisory BoardsAdvisor
Details
activity Boehringer Ingelheim
Advisory BoardsAdvisor
Details
activity Cardionomic
Advisory BoardsAdvisor
Details
activity 3ive Labs
Advisory BoardsAdvisor
Details
activity Lilly
Advisory BoardsAdvisor
Details
See All Achievements
Clinical Care
Overview
Jeffrey Testani, MD, MTR (master of science in translational research) is a cardiologist who specializes in advanced heart failure. People with advanced heart failure experience shortness of breath and other symptoms even while at rest despite conventional therapies and strategies.
Dr. Testani’s work focuses on the connections between fluid build-up and heart failure. When the heart is unable to pump an adequate supply of blood to the body, the kidneys respond by increasing the volume of fluids. Dr. Testani and fellow researchers have determined that a diabetes medication can reduce fluid build-up in diabetic patients with heart failure.
Dr. Tetany’s current research involves studying hundreds of heart patients, producing 500,000 biospecimens, or samples, that can be used to determine specific paths and characteristics that lead to heart failure.
Dr. Testani is an associate professor of medicine (cardiology) at Yale School of Medicine.
Clinical Specialties
Cardiovascular Medicine; Heart Failure
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
News
News
October 25, 2024
Can a ‘Kidney Action Team’ Improve Patient Outcomes?Read moreabout Can a ‘Kidney Action Team’ Improve Patient Outcomes?
April 01, 2024
Yale Faculty Present Groundbreaking Clinical Research at the 2024 American College of Cardiology Scientific SessionsRead moreabout Yale Faculty Present Groundbreaking Clinical Research at the 2024 American College of Cardiology Scientific Sessions
February 26, 2024
Reanalyzing the Impact of COVID-19 on the KidneysRead moreabout Reanalyzing the Impact of COVID-19 on the Kidneys
July 13, 2023
Department of Internal Medicine Promotions and Appointments (July 2023)Read moreabout Department of Internal Medicine Promotions and Appointments (July 2023)
See All News
Get In Touch
Contacts
jeffrey.testani@yale.edu
Appointment Number
203.785.7191
Clinic Fax Number
203.785.2917
Mailing Address
Cardiovascular Medicine
PO Box 208017
New Haven, CT 06520
United States
Locations
Patient Care Locations
Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
